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The results show that the number of patients in Al-Iskan District surpassed that in Al-Harthiyya. Moreover, in studying the spread of Malaria disease and its relation to Sickle cell anemia, it has been noticed that patients infected with Malaria were more prone to have sickle cell anemia as in reflected in the high level of infected patients in Al-Iskan District. In investigation the relation between the patient’s gender and this type of anemia, the study revealed that the number of male patients was lesser than of females in both Al-Iskan and Al-Harthiyya District. The study also revealed that majority of patients with sickle cell anemia are with in age group that ranges 11-25 years in Al-Iskan, While the results were different concerning Al-Harthiyya patients. The age groups that range 1-5 years as well as those 11-15 years are more infected with sickle cell anemia in the latter district.