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Many agents disrupt the cell cycle and its signaling circuits leading to cancer progress. Cancer therapy is performed by surgery, radiation, and chemical drugs remaining some side effects.

To evaluate the anticancer traits of herbal medicines.

We collected previously published data in searching engines (Web of Science, PubMed, Medline, and SCOPUS) by searching key words “herbal medicine,” “anticancer effect,” “compounds,” and “fractions.”

Herbal medicines have unraveled anticancer effects mostly through cancer cells apoptosis via blocking NF-κB pathway by curcumin and terpenoides; CD95 signaling and enhancement of CD95L expression by resveratrol; and inhibiting tyrosine kinas, angiogenesis, and cell cycle arrest in G2/M phase by β-lapachone-genistein and cytochrome-c release into the cytosol and caspase-9 activation by biocalein and quercetin …