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This paper is concerned with solving the single machine total weighted tardiness problem with sequence dependent setup times by a discrete differential evolution algorithm developed by the authors recently. Its performance is enhanced by employing different population initialization schemes based on some constructive heuristics such as the well-known NEH and the greedy randomized adaptive search procedure (GRASP) as well as some priority rules such as the earliest weighted due date (EWDD) and the apparent tardiness cost with setups (ATCS). Additional performance enhancement is further achieved by the inclusion of a referenced local search (RLS) in the algorithm together with the use of destruction and construction (DC) procedure when obtaining the mutant population. Furthermore, to facilitate the greedy job insertion into a partial solution which will be employed in the NEH, GRASP, DC heuristics …