作者
Antonio Nenna, Cristiano Spadaccio, Mario Lusini, Luca Ulianich, Massimo Chello, Francesco Nappi
发表日期
2015/4/1
期刊
Recent patents on cardiovascular drug discovery
卷号
10
期号
1
页码范围
10-33
出版商
Bentham Science Publishers
简介
Diabetes is a major risk factor for cardiovascular disease, and recent advances in research indicate that a detailed understanding of the pathophysiology of its effects is mandatory to reduce diabetes-related mortality and morbidity. Advanced Glycation End Products (AGEs) play a central role in the genesis and progression of complications of both type 1 and type 2 diabetes mellitus, and have been found to be important even in non-diabetic patients as a marker of cardiovascular disease. AGEs have a profound impact on patient's prognosis regardless of the glycemic control, and therefore pharmacologic approaches against AGEs accumulation have been proposed over the years to treat cardiovascular diseases, parallel to a more detailed understanding of AGEs pathophysiology. Compounds with anti-AGEs effects are currently under investigation in both pre-clinical and clinical scenarios, and many of the drugs …
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