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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common type of dementia among older people. The number of patients with AD will grow rapidly each year and AD is the fifth leading cause of death for those aged 65 and older. In recent years, one of the main challenges for medical investigators has been the early diagnosis of patients with AD because an early diagnosis can provide greater opportunities for patients to be eligible for more clinical trials and they will have enough time to plan for future, medical and financial decisions. An established risk factor for AD is mild cognitive impairment (MCI) which is described as a transitional state between normal aging and AD patients. Hence an accurate and reliable diagnosis of MCI can be very effective and helpful for early diagnosis of AD. Therefore in this paper we present a novel and efficient method based on pseudo Zernike …