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In this study, we propose a hybrid approach involving feature extraction, feature selection, and optimized learning for the diagnosis of multiple sclerosis (MS), which can detect the lesion caused by MS plaques in the brain using magnetic resonance imaging analysis. A major challenge associated with lesion diagnosis by neurologists is that it is a time-consuming process and demands high expertise; therefore, researchers have been stimulated to find an auto-diagnose method of the disease. Given the high resemblance of MS plaque-induced lesions and other lesions such as Alzheimer’s or dementia, scant research has explored the diagnosis of MS-induced lesions, most of which suffering from the lack of an efficient and accurate method. Informed by the need for a precise hybrid model for the classification of MS plaques and other comparable lesions, a solution is proposed that utilizes an efficient model …