作者
Daniel DiCorpo, Sheila M Gaynor, Emily M Russell, Kenneth E Westerman, Laura M Raffield, Timothy D Majarian, Peitao Wu, Chloé Sarnowski, Heather M Highland, Anne Jackson, Natalie R Hasbani, Paul S de Vries, Jennifer A Brody, Bertha Hidalgo, Xiuqing Guo, James A Perry, Jeffrey R O’Connell, Samantha Lent, May E Montasser, Brian E Cade, Deepti Jain, Heming Wang, Ricardo D’Oliveira Albanus, Arushi Varshney, Lisa R Yanek, Leslie Lange, Nicholette D Palmer, Marcio Almeida, Juan M Peralta, Stella Aslibekyan, Abigail S Baldridge, Alain G Bertoni, Lawrence F Bielak, Chung-Shiuan Chen, Yii-Der Ida Chen, Won Jung Choi, Mark O Goodarzi, James S Floyd, Marguerite R Irvin, Rita R Kalyani, Tanika N Kelly, Seonwook Lee, Ching-Ti Liu, Douglas Loesch, JoAnn E Manson, Ryan L Minster, Take Naseri, James S Pankow, Laura J Rasmussen-Torvik, Alexander P Reiner, Muagututi’a Sefuiva Reupena, Elizabeth Selvin, Jennifer A Smith, Daniel E Weeks, Huichun Xu, Jie Yao, Wei Zhao, Stephen Parker, Alvaro Alonso, Donna K Arnett, John Blangero, Eric Boerwinkle, Adolfo Correa, L Adrienne Cupples, Joanne E Curran, Ravindranath Duggirala, Jiang He, Susan R Heckbert, Sharon LR Kardia, Ryan W Kim, Charles Kooperberg, Simin Liu, Rasika A Mathias, Stephen T McGarvey, Braxton D Mitchell, Alanna C Morrison, Patricia A Peyser, Bruce M Psaty, Susan Redline, Alan R Shuldiner, Kent D Taylor, Ramachandran S Vasan, Karine A Viaud-Martinez, Jose C Florez, James G Wilson, Robert Sladek, Stephen S Rich, Jerome I Rotter, Xihong Lin, Josée Dupuis, James B Meigs, Jennifer Wessel, Alisa K Manning
发表日期
2022/7/28
期刊
Communications biology
卷号
5
期号
1
页码范围
756
出版商
Nature Publishing Group UK
简介
The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied mostly through genome arrays, resulting in over 100 associated variants. We extended this work with high-coverage whole genome sequencing analyses from fifteen cohorts in NHLBI’s Trans-Omics for Precision Medicine (TOPMed) program. Over 23,000 non-diabetic individuals from five race-ethnicities/populations (African, Asian, European, Hispanic and Samoan) were included. Eight variants were significantly associated with FG or FI across previously identified regions MTNR1B, G6PC2, GCK, GCKR and FOXA2. We additionally characterize suggestive associations with FG or FI near previously identified SLC30A8, TCF7L2, and ADCY5 regions as well as APOB, PTPRT, and ROBO1. Functional annotation resources including the Diabetes Epigenome Atlas were compiled for each signal (chromatin states, annotation …
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