作者
Steven G Deeks, Nancie Archin, Paula Cannon, Simon Collins, R Brad Jones, Marein AWP de Jong, Olivier Lambotte, Rosanne Lamplough, Thumbi Ndung’u, Jeremy Sugarman, Caroline T Tiemessen, Linos Vandekerckhove, Sharon R Lewin, International AIDS Society (IAS) Global Scientific Strategy working group Core Leadership Group Deeks Steven 1 Lewin Sharon 17 de Jong Marein 6, Working Group 1 (Understanding HIV reservoirs) Ndhlovu Zaza 18 Chomont Nicolas 19 Brumme Zabrina 20 Deng Kai 21 Jasenosky Luke 22 Jefferys Richard 23 Orta-Resendiz Aurelio 24, Working Group 2 (HIV reservoir measurement) Mardarelli Frank 25 Nijhuis Monique 26 Bar Katharine 27 Howell Bonnie 28 Schneider Alex 29 Turk Gabriela 30 31 Nabatanzi Rose 32, Working Group 3 (Mechanisms of virus control) Blankson Joel 33 Garcia J. Victor 34 Paiardini Mirko 35 Lunzen Jan van 36 Antoniadi Christina 37 Côrtes Fernanda Heloise 38, Working Group 4 (Targeting the provirus) Valente Susana 39 Søgaard Ole S. 40 Diaz Ricardo Sobhie 41 Ott Melannie 42 Dunham Richard (Rick) 43 Schwarze Siegfried 44 Patrigeon Santiago Perez 45 Nabukenya Josephine 46, Working Group 5 (Targeting the immune system) Caskey Marina 47 Mothe Beatriz 48 Wang Fu Sheng 49 Fidler Sarah 50 SenGupta Devi 51 Dressler Stephan 52 Matoga Mitch 53, Working Group 6 (Cell and gene therapy) Kiem Hans-Peter 54 Tebas Pablo 27 Kityo Cissy 55 Dropulic Boro 56 Louella Michael 57 Das Kumitaa Theva 58, Working Group 7 (Paediatric remission and cure) Persaud Deborah 59 Chahroudi Ann 60 Luzuriaga Katherine 61 Puthanakit Thanyawee 62 Safrit Jeffrey 63 Masheto Gaerolwe 64, Working Group 8:(Social, behavioral and ethical aspects of cure) Dubé Karine 65 Power Jennifer 66 Salzwedel Jessica 67 Likhitwonnawut Udom 68 Taylor Jeff 69 Nuh Oguzhan Latif 70 Dong Krista 11 Kankaka Edward Nelson 71
发表日期
2021/12
来源
Nature medicine
卷号
27
期号
12
页码范围
2085-2098
出版商
Nature Publishing Group US
简介
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cure. HIV can integrate in the host genome and persist for the life span of the infected cell. These latently infected cells are not recognized as foreign because they are largely transcriptionally silent, but contain replication-competent virus that drives resurgence of the infection once ART is stopped. With a combination of immune activators, neutralizing antibodies, and therapeutic vaccines, some nonhuman primate models have been cured, providing optimism for these approaches now being evaluated in human clinical trials. In vivo delivery of gene-editing tools to either target the virus, boost immunity or protect cells from infection, also holds promise for future HIV cure strategies. In this Review, we discuss advances related to HIV cure in the last 5 years, highlight remaining knowledge gaps and …
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SG Deeks, N Archin, P Cannon, S Collins, RB Jones… - Nature medicine, 2021