查看文章

Most autopsy samples are based on clinical cohorts or case series; the distribution of neuropathologies may be biased in these samples compared to the general population. A small number of population‐based neuropathology cohorts address these concerns but are often limited by small sample sizes and restrictions to specific geographic locations or groups. Harmonization would allow comparisons across settings and increases in precision of estimates.

We leveraged data from the Religious Orders Study and Memory and Aging Project (N=1882), the Adult Changes in Thought study (N=721), the Cognitive Function and Ageing Studies (N=444), and the Cambridge City over‐75s Cohort Study (N=241). First, we identified measures in common across cohorts or a subset of cohorts and documented protocol differences. We characterized distributions of pathologies by age group (80‐89 vs …