作者
Dorothée Obach, Anna Solastie, Oona Liedes, Saimi Vara, Eva Krzyżewska‐Dudek, Luise Brinkmann, Anu Haveri, Charlotte C Hammer, Timothée Dub, Seppo Meri, Tobias L Freitag, Outi Lyytikäinen, Merit Melin
发表日期
2022/9
期刊
Immunity, inflammation and disease
卷号
10
期号
9
页码范围
e679
简介
Introduction
Long‐term care facilities (LTCF) residents are at high risk for severe coronavirus disease 2019 (COVID‐19), and therefore, COVID‐19 vaccinations were prioritized for residents and personnel in Finland at the beginning of 2021.
Methods
We investigated COVID‐19 outbreaks in two LTCFs, where residents were once or twice vaccinated. After the outbreaks we measured immunoglobulin G (IgG) antibodies to severe acute respiratory syndrome coronavirus 2 spike glycoprotein, neutralizing antibody (NAb) titers, and cell‐mediated immunity markers from residents and healthcare workers (HCWs).
Results
In LTFC‐1, the outbreak was caused by an Alpha variant (B.1.1.7) and the attack rate (AR) among once vaccinated residents was 23%. In LTCF‐2 the outbreak was caused by a Beta variant (B.1.351). Its AR was 47% although all residents had received their second dose 1 month before the outbreak …
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D Obach, A Solastie, O Liedes, S Vara… - Immunity, inflammation and disease, 2022