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In recent years, the ambition to achieve very high data rates in wireless communication systems has fuelled the study of multiple-input multiple-output (MIMO) architectures and has resulted in the need for more advanced equalization techniques. Currently, the wireless industry is at a point where typical time-domain equalization solutions are becoming too complex to implement in MIMO systems. In this paper, a single-carrier frequency-domain equalization (SC-FDE) solution is presented that utilizes the minimum mean-squared error (MMSE) criterion to perform equalization on the received message. The error-rate performance of a system that employs this MMSE equalizer is analyzed.