作者
L Keoki Williams, Badri Padhukasahasram, Brian K Ahmedani, Edward L Peterson, Karen E Wells, Esteban González Burchard, David E Lanfear
发表日期
2014/9/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
99
期号
9
页码范围
3160-3168
出版商
Oxford University Press
简介
Context
Metformin is considered first-line treatment for type 2 diabetes mellitus. However, little is known about its effects in African American individuals.
Objective
The objective of the study was to assess whether metformin's effect on glycemic control differs by race-ethnicity
Design
Electronic health records were used to identify adults who had a diagnosis of diabetes, two or more fills of metformin, and two or more glycated hemoglobin (HbA1c) measurements. Pharmacy claims were used to estimate metformin exposure based on fill frequency and dose dispensed. Regression analyses modeled the relationship between metformin exposure and HbA1c levels. Analyses were stratified by race-ethnicity and baseline HbA1c values.
Setting
The study was conducted at a large health system in southeast Michigan.
Main Outcome …
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LK Williams, B Padhukasahasram, BK Ahmedani… - The Journal of Clinical Endocrinology & Metabolism, 2014