作者
Matthias M Engelen, Christophe Vandenbriele, Valérie Spalart, Caroline P Martens, Bert Vandenberk, Pieter Sinonquel, Natalie Lorent, Paul De Munter, Rik Willems, Joost Wauters, Alexander Wilmer, Dieter Dauwe, Jan Gunst, Ipek Guler, Stefan Janssens, Kimberly Martinod, Griet Pieters, Kathelijne Peerlinck, Peter Verhamme, Thomas Vanassche
发表日期
2022/3/1
期刊
Research and Practice in Thrombosis and Haemostasis
卷号
6
期号
3
页码范围
e12683
出版商
Elsevier
简介
Background
Venous thromboembolism (VTE) frequently occurs in hospitalized patients with coronavirus disease 2019 (COVID‐19). The optimal dose of anticoagulation for thromboprophylaxis in COVID‐19 is unknown.
Aims
To report VTE incidence and bleeding before and after implementing a hospital‐wide intensified thromboprophylactic protocol in patients with COVID‐19.
Methods
On March 31, 2020, we implemented an intensified thromboprophylactic protocol consisting of 50 IU anti‐Xa low molecular weight heparin (LMWH)/kg once daily at the ward, twice daily at the intensive care unit (ICU). We included all patients hospitalized in a tertiary care hospital with symptomatic COVID‐19 between March 7 and July 1, 2020. The primary outcome was the incidence of symptomatic or subclinical VTE and major bleeding during admission. Routine ultrasound screening for VTE was performed whenever logistically …
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MM Engelen, C Vandenbriele, V Spalart, CP Martens… - Research and Practice in Thrombosis and …, 2022