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Aims Long-standing ulcerative colitis (UC) has an increased risk for developing colorectal dysplasia and neoplasia. Dye-based chromoendoscopy (DCE) and virtual chromoendoscopy (VCE) increase detection of neoplastic lesions. However, limited data are available on the impact of i-scan VCE for UC neoplasia detection. We undertook a prospective randomized controlled trial to compare the neoplasia detection between DCE and i-scan in patients with long-standing UC.

Methods In 4 European hospitals, 136 patients with long-standing UC (mean disease duration 19.88 (DCE) vs 18.49 years (i-scan)) were randomized (1: 1) to either DCE with methylene blue 0.1%(n= 71) or i-scan (n= 65). Biopsies were taken from visible lesions and surrounding mucosa. Neoplasic lesions included any type of dysplasia, polyp or carcinoma. Statistical analysis was performed using t-test for continuous data and Fishers’ exact for …