作者
Hanneke JM Kerkhof, Rik J Lories, Ingrid Meulenbelt, Ingileif Jonsdottir, Ana M Valdes, Pascal Arp, Thorvaldur Ingvarsson, Mila Jhamai, Helgi Jonsson, Lisette Stolk, Gudmar Thorleifsson, Guangju Zhai, Feng Zhang, Yanyan Zhu, Ruud Van Der Breggen, Andrew Carr, Michael Doherty, Sally Doherty, David T Felson, Antonio Gonzalez, Bjarni V Halldorsson, Deborah J Hart, Valdimar B Hauksson, Albert Hofman, John PA Ioannidis, Margreet Kloppenburg, Nancy E Lane, John Loughlin, Frank P Luyten, Michael C Nevitt, Neeta Parimi, Huibert AP Pols, Fernando Rivadeneira, Eline P Slagboom, Unnur Styrkársdóttir, Aspasia Tsezou, Tom Van De Putte, Joseph Zmuda, Tim D Spector, Kari Stefansson, André G Uitterlinden, Joyce BJ Van Meurs
发表日期
2010/2
期刊
Arthritis & Rheumatism: Official Journal of the American College of Rheumatology
卷号
62
期号
2
页码范围
499-510
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
To identify novel genes involved in osteoarthritis (OA), by means of a genome‐wide association study.
Methods
We tested 500,510 single‐nucleotide polymorphisms (SNPs) in 1,341 Dutch Caucasian OA cases and 3,496 Dutch Caucasian controls. SNPs associated with at least 2 OA phenotypes were analyzed in 14,938 OA cases and ∼39,000 controls. Meta‐analyses were performed using the program Comprehensive Meta‐analysis, with P values <1 × 10−7 considered genome‐wide significant.
Results
The C allele of rs3815148 on chromosome 7q22 (minor allele frequency 23%; intron 12 of the COG5 gene) was associated with a 1.14‐fold increased risk (95% confidence interval 1.09–1.19) of knee and/or hand OA (P = 8 × 10−8) and also with a 30% increased risk of knee OA progression (95% confidence interval 1.03–1.64) (P = 0.03). This SNP is in almost complete linkage disequilibrium with …
引用总数
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A genome‐wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22
HJM Kerkhof, RJ Lories, I Meulenbelt, I Jonsdottir… - Arthritis & Rheumatism: Official Journal of the American …, 2010