作者
Kalliope Panoutsopoulou, Lorraine Southam, KS Elliott, N Wrayner, Guangju Zhai, C Beazley, Gudmar Thorleifsson, NK Arden, A Carr, K Chapman, P Deloukas, M Doherty, A McCaskie, WER Ollier, SH Ralston, TD Spector, AM Valdes, GA Wallis, JM Wilkinson, E Arden, K Battley, H Blackburn, FJ Blanco, S Bumpstead, LA Cupples, AG Day-Williams, K Dixon, SA Doherty, T Esko, E Evangelou, D Felson, JJ Gomez-Reino, A Gonzalez, A Gordon, R Gwilliam, BV Halldorsson, VB Hauksson, A Hofman, SE Hunt, JPA Ioannidis, T Ingvarsson, I Jonsdottir, H Jonsson, R Keen, HJM Kerkhof, MG Kloppenburg, N Koller, N Lakenberg, NE Lane, AT Lee, A Metspalu, I Meulenbelt, MC Nevitt, F O'neill, N Parimi, SC Potter, I Rego-Perez, JA Riancho, K Sherburn, PE Slagboom, K Stefansson, U Styrkarsdottir, M Sumillera, D Swift, U Thorsteinsdottir, A Tsezou, AG Uitterlinden, JBJ Van Meurs, B Watkins, M Wheeler, S Mitchell, Y Zhu, JM Zmuda, E Zeggini, J Loughlin, arcOGEN Consortium
发表日期
2011/5/1
期刊
Annals of the rheumatic diseases
卷号
70
期号
5
页码范围
864-867
出版商
BMJ Publishing Group Ltd
简介
Objectives
The genetic aetiology of osteoarthritis has not yet been elucidated. To enable a well-powered genome-wide association study (GWAS) for osteoarthritis, the authors have formed the arcOGEN Consortium, a UK-wide collaborative effort aiming to scan genome-wide over 7500 osteoarthritis cases in a two-stage genome-wide association scan. Here the authors report the findings of the stage 1 interim analysis.
Methods
The authors have performed a genome-wide association scan for knee and hip osteoarthritis in 3177 cases and 4894 population-based controls from the UK. Replication of promising signals was carried out in silico in five further scans (44 449 individuals), and de novo in 14 534 independent samples, all of European descent.
Results
None of the association signals the authors identified reach genome-wide levels of statistical significance, therefore stressing the need for corroboration in …
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K Panoutsopoulou, L Southam, KS Elliott, N Wrayner… - Annals of the rheumatic diseases, 2011