作者
Apinya Leerapun, Sri V Suravarapu, John P Bida, Raynell J Clark, Elizabeth L Sanders, Teresa A Mettler, Linda M Stadheim, Ileana Aderca, Catherine D Moser, David M Nagorney, Nicholas F LaRusso, Piet C de Groen, KV Narayanan Menon, Konstantinos N Lazaridis, Gregory J Gores, Michael R Charlton, Rosebud O Roberts, Terry M Therneau, Jerry A Katzmann, Lewis R Roberts
发表日期
2007/3/1
期刊
Clinical Gastroenterology and Hepatology
卷号
5
期号
3
页码范围
394-402
出版商
WB Saunders
简介
Background & Aims
The percentage of Lens culinaris agglutinin-reactive (α)-fetoprotein (AFP-L3%) is proposed as a diagnostic and prognostic marker for hepatocellular carcinoma (HCC). We evaluated the utility of AFP-L3% for diagnosis of HCC in a US referral population.
Methods
This retrospective study included 272 patients: 166 with HCC and 106 with benign liver disease (chronic liver disease, 77; benign liver mass, 29). The AFP-L3% was measured using a clinical auto-analyzer.
Results
The AFP-L3% is not reported for a total α-fetoprotein (AFP) less than 10 ng/mL, and all patients with an AFP greater than 200 ng/mL had HCC; thus the AFP-L3% was noninformative for these patients. In patients with a total AFP of 10–200 ng/mL, an AFP-L3% greater than 10% had a sensitivity of 71% and a specificity of 63% for diagnosis of HCC. An AFP-L3% greater than 35% had a reduced sensitivity of 33%, but an …
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