作者
Pia Leete, Richard A Oram, Timothy J McDonald, Beverley M Shields, Clemens Ziller, TIGI study team Bart O. Roep Timothy I. Tree Kashyap Patel Suzy Hammersley Robert Bolt Anita V. Hill, Andrew T Hattersley, Sarah J Richardson, Noel G Morgan
发表日期
2020/6
期刊
Diabetologia
卷号
63
页码范围
1258-1267
出版商
Springer Berlin Heidelberg
简介
Aims/hypothesis
It is unclear whether type 1 diabetes is a single disease or if endotypes exist. Our aim was to use a unique collection of pancreas samples recovered soon after disease onset to resolve this issue.
Methods
Immunohistological analysis was used to determine the distribution of proinsulin and insulin in the islets of pancreas samples recovered soon after type 1 diabetes onset (<2 years) from young people diagnosed at age <7 years, 7–12 years and ≥13 years. The patterns were correlated with the insulitis profiles in the inflamed islets of the same groups of individuals. C-peptide levels and the proinsulin:C-peptide ratio were measured in the circulation of a cohort of living patients with longer duration of disease but who were diagnosed in these same age ranges.
Results
Distinct patterns of proinsulin localisation were seen in the islets of people with recent-onset type 1 diabetes, which differed …
学术搜索中的文章
P Leete, RA Oram, TJ McDonald, BM Shields, C Ziller… - Diabetologia, 2020