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Substantial progress has been made in Ti alloys’ properties and chemical composition. However, the effect of porosity and indium content on biocompatibility and corrosion behavior has not been sufficiently studied. Indium (In) is a promising nontoxic element that can replace other toxic elements, while porosity is associated with a good biological response. The purpose of this paper is to evaluate the achievability of three Ti–In alloys with 2.5, 5, and 10 wt.% Indium by powder metallurgy methods as dental prostheses. The findings of the present work showed that In acted as a grain refiner, and allowed us to obtain an 11.2-fold reduction for the Ti–10In sample than for the Ti–2.5In alloy. The total porosity of the Ti–In alloys decreased according to In content, however, grain size and In content showed a greater effect on the mechanical behavior in comparison with the effect of porosity, probably because of the low …