作者
Chainika Khatana, Neeraj K Saini, Sasanka Chakrabarti, Vipin Saini, Anil Sharma, Reena V Saini, Adesh K Saini
发表日期
2020
来源
Oxidative medicine and cellular longevity
卷号
2020
期号
1
页码范围
5245308
出版商
Hindawi
简介
Dyslipidaemia has a prominent role in the onset of notorious atherosclerosis, a disease of medium to large arteries. Atherosclerosis is the prime root of cardiovascular events contributing to the most considerable number of morbidity and mortality worldwide. Factors like cellular senescence, genetics, clonal haematopoiesis, sedentary lifestyle‐induced obesity, or diabetes mellitus upsurge the tendency of atherosclerosis and are foremost pioneers to definitive transience. Accumulation of oxidized low‐density lipoproteins (Ox‐LDLs) in the tunica intima triggers the onset of this disease. In the later period of progression, the build‐up plaques rupture ensuing thrombosis (completely blocking the blood flow), causing myocardial infarction, stroke, and heart attack, all of which are common atherosclerotic cardiovascular events today. The underlying mechanism is very well elucidated in literature but the therapeutic …
引用总数
学术搜索中的文章
C Khatana, NK Saini, S Chakrabarti, V Saini, A Sharma… - Oxidative medicine and cellular longevity, 2020