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Application of drug conjugated iron oxide hematite (α-Fe2O3) nanoparticles are of tremendous interest in biomedicine nowadays. Meanwhile, green production of iron oxide nanoparticles is gaining favour due to its sustainability, ease of usage, and biocompatibility. Therefore, this work reports on the use of hexahydrate ferric chloride andnerium oleanderflower extract to synthesize nanoscaled hematite (α-Fe2O3) iron oxide particles conjugated with various drugs for antibacterial agents. Diverse morphological, physicochemical, structural, optical, and magnetic characteristics have been characterized using FESEM, EDX, XRD, UV–vis, FTIR, Raman and vibrating sample magnetometer. The synthesis of the polyshaped iron oxide nanoparticles, with average sizes ranging from 47.2±20 nm, was accomplished. Furthermore, temperature-dependent variations in magnetic behavior were observed during calcination. The …