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Proteases, also named as peptidases, proteinases, or proteolytic enzymes, are hydrolytic enzymes that hydrolyze peptide bonds within protein molecules. Serine proteases are considered as the largest proteolytic class belonging to S1 family of the PA clan superfamily which comprises the largest number of serine proteases. Serine proteases utilize activated serine in its substrate-binding site to catalytically hydrolyze peptide bonds. Serine proteases are involved in many important developmental and normal physiological processes of living systems including humans. Abnormal expression of these proteases leads to several destructive diseases, inflammatory disorders as well as cancer. These serine proteases are not only important for physiological functioning of living organisms, but they also have commercial significance. Proteases from microbes are preferred over other sources because of their ease of …