作者
Stephan Nopp, Clemens P Spielvogel, Sabine Schmaldienst, Renate Klauser-Braun, Matthias Lorenz, Benedikt N Bauer, Ingrid Pabinger, Marcus Saeemann, Oliver Königsbrügge, Cihan Ay
发表日期
2022/9
期刊
Thrombosis and Haemostasis
卷号
122
期号
09
页码范围
1558-1566
出版商
Georg Thieme Verlag KG
简介
Background Patients with end-stage kidney disease (ESKD) on hemodialysis (HD) are at increased risk for bleeding. However, despite relevant clinical implications regarding dialysis modalities or anticoagulation, no bleeding risk assessment strategy has been established in this challenging population.
Methods Analyses on bleeding risk assessment models were performed in the population-based Vienna InVestigation of Atrial fibrillation and thromboemboLism in patients on hemoDialysIs (VIVALDI) study including 625 patients. In this cohort study, patients were prospectively followed for a median observation period of 3.5 years for the occurrence of major bleeding. First, performances of existing bleeding risk scores (i.e., HAS-BLED, HEMORR2HAGES, ATRIA, and four others) were evaluated in terms of discrimination and calibration. Second, four machine learning-based prediction models that included …
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