作者
Salvatore Caccamese, Giovanna Scivoli, Salvatore Bianca, Juan Manuel López-Romero, Francisco Javier Ortiz-López
发表日期
2006/9/29
期刊
Journal of Chromatography A
卷号
1129
期号
1
页码范围
140-144
出版商
Elsevier
简介
The HPLC enantiomeric separation of the racemic cularinoid alkaloids N-p-methoxy-1,α-dihydroaristoyagonine (1) and 4′,5′-demethoxy-1,α-dihydroaristoyagonine (2) was accomplished using five chiral stationary phases (CSPs), some of them polysaccharide-derived ones. The molecular size and conjugative effect strongly affect the different enantioselectivity of the compounds 1 and 2 on the various CSPs investigated. Single enantiomers of 1 were isolated by repeated injections on an analytical HPLC column, and their circular dichroism spectra and optical rotations were measured. The cytotoxicity of the isolated enantiomers was measured on a human colon carcinoma cell line and compared with that of the racemic compound.
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S Caccamese, G Scivoli, S Bianca, JM López-Romero… - Journal of Chromatography A, 2006