作者
Noureddine El Aouad, Guiomar Perez-Moreno, Paula Sanchez, Juan Cantizani, Francisco Javier Ortiz-López, Jesus Martin, Victor Gonzalez-Menendez, Luis M Ruiz-Perez, Dolores Gonzalez-Pacanowska, Francisca Vicente, Gerald Bills, Fernando Reyes
发表日期
2012/6/22
期刊
Journal of natural products
卷号
75
期号
6
页码范围
1228-1230
出版商
American Chemical Society and American Society of Pharmacognosy
简介
A new naphthopyrone derivative, lasionectrin (1), was isolated from fermentations of an Acremonium-like fungus provisionally identified as a Lasionectria sp. (Ascomycota, Hypocreales) and isolated from forest leaf litter from Equatorial Guinea. Its structure was determined by a combination of spectroscopic techniques, including UV, (+)-HRESIMS, and 1D and 2D NMR spectroscopy, and comparison with published data for related fungal metabolites. Compound 1 inhibited the growth of Plasmodium falciparum with an IC50 value of 11 μM.
学术搜索中的文章
N El Aouad, G Perez-Moreno, P Sanchez, J Cantizani… - Journal of natural products, 2012