作者
Ticiana Ferreira Larocca, Carolina Thé Macêdo, Bruno Solano de Freitas Souza, Yuri M Andrade-Souza, Cristiane Flora Villarreal, André Costa Matos, Daniela Nascimento Silva, Kátia Nunes da Silva, Daniela da Silva Paixão, Milena da Rocha Bezerra, Rodrigo Leal Alves, Milena Botelho Pereira Soares, Ricardo Ribeiro dos Santos
发表日期
2017/10/1
期刊
Cytotherapy
卷号
19
期号
10
页码范围
1189-1196
出版商
Elsevier
简介
Background aims
The potential of cell therapies to improve neurological function in subjects with spinal cord injury (SCI) is currently under investigation. In this context, the choice of cell type, dose, route and administration regimen are key factors. Mesenchymal stromal cells (MSCs) can be easily obtained, expanded and are suitable for autologous transplantation. Here we conducted a pilot study that evaluated safety, feasibility and potential efficacy of intralesional MSCs transplantation performed through image-guided percutaneous injection, in subjects with chronic complete SCI.
Methods
Five subjects with chronic traumatic SCI (>6 months), at thoracic level, classified as American Spinal Cord Injury Association impairment scale (AIS) grade A, complete injury, were included. Somatosensory evoked potentials (SSEP), spinal magnetic resonance imaging (MRI) and urodynamics were assessed before and after …
学术搜索中的文章
TF Larocca, CT Macêdo, BS de Freitas Souza… - Cytotherapy, 2017