作者
Kyan James Allahdadi, Thaís Alves de Santana, Girlaine Café Santos, Carine Machado Azevedo, Roberta Alves Mota, Carolina Kymie Nonaka, Daniela Nascimento Silva, Clarissa Xavier Resende Valim, Cláudio Pereira Figueira, Washington Luis Conrado Dos Santos, Renan Fernandes do Espirito Santo, Afrânio Ferreira Evangelista, Cristiane Flora Villarreal, Ricardo Ribeiro Dos Santos, Bruno Solano Freitas de Souza, Milena Botelho Pereira Soares
发表日期
2019/12
期刊
Stem Cell Research & Therapy
卷号
10
页码范围
1-14
出版商
BioMed Central
简介
Background
Survival and therapeutic actions of bone marrow-derived mesenchymal stem cells (BMMSCs) can be limited by the hostile microenvironment present during acute spinal cord injury (SCI). Here, we investigated whether BMMSCs overexpressing insulin-like growth factor 1 (IGF-1), a cytokine involved in neural development and injury repair, improved the therapeutic effects of BMMSCs in SCI.
Methods
Using a SCI contusion model in C57Bl/6 mice, we transplanted IGF-1 overexpressing or wild-type BMMSCs into the lesion site following SCI and evaluated cell survival, proliferation, immunomodulation, oxidative stress, myelination, and functional outcomes.
Results
BMMSC-IGF1 transplantation was associated with increased cell survival and recruitment of endogenous neural progenitor cells compared to …
学术搜索中的文章
KJ Allahdadi, TA de Santana, GC Santos, CM Azevedo… - Stem Cell Research & Therapy, 2019