作者
Junyang Li, Xiaojian Li, Tao Luo, Ran Wang, Chichi Liu, Shuxun Chen, Dongfang Li, Jianbo Yue, Shuk-han Cheng, DJSR Sun
发表日期
2018/6/27
期刊
Science robotics
卷号
3
期号
19
页码范围
eaat8829
出版商
American Association for the Advancement of Science
简介
The precise delivery of targeted cells through magnetic field–driven microrobots/carriers is a promising technique for targeted therapy and tissue regeneration. This paper presents a microrobot designed with a burr-like porous spherical structure for carrying and delivering targeted cells in vivo under a magnetic gradient field–driven mechanism. The robot was fabricated by using three-dimensional laser lithography and coated with Ni for magnetic actuation and Ti for biocompatibility. Numerical and experimental studies demonstrated that the proposed microrobot design could enhance magnetic driving capability, promote cell-carrying capacity, and benefit cell viability. Microrobots loaded with cells could be automatically controlled to reach a desired site by using a self-constructed electromagnetic coil system, as verified by in vivo transport of cell-cultured microrobots in zebrafish embryos. The carried cells could be …
引用总数
20182019202020212022202320243305683776432
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