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This study explores the utility of quantitative structure–pharmacokinetic relationship models of the disposition parameters: clearance (CL), apparent volume of drug distribution (V_ap), fractal clearance (CL_f), and fractal volume (v_f), for a series of 23 cephalosporins used in therapeutics. Data for CL, V_ap and elimination half-life were obtained from literature, whereas CL_f and v_f were calculated from the literature data for CL and V_ap, respectively. A variety of descriptors expressing acidity/basicity, lipophilicity, molecular size and hydrogen bonding properties were estimated using computer packages. For each pharmacokinetic parameter, projection to latent structures (PLS) was applied to the total dataset. Adequate PLS models, with one principal component, were derived for CL, CL_f, V_ap and v_f. Identical descriptors were found to be significant for the two clearance as well as for the two volume of distribution terms. CL …