查看文章

Purpose. (i) Evaluate the predictive performance of the fractal volume of drug distribution, v _f, (Pharm. Res.18, 1056, 2001), (ii) develop the concept of the fractal clearance, CL _f, which is the clearance analogue of v _f, (iii) examine the utility of CL _f in allometric studies, (iv) develop allometric relationships for the elimination half-life, t _1/2 , and (v) evaluate the use of v _f and CL _f in predicting the volume of drug distribution, V _ap, clearance, CL, and elimination half-life, t _1/2 .

Methods. Estimates for v _f of various drugs were obtained and correlated with body mass using data only from animal species. A comparison was made between the predicted and actual v _f values for humans. For a variety of animal species CL _f values were estimated from the equation:

The allometric equations developed using CL _f were compared …