作者
F Daniel Ramirez, Pouya Motazedian, Richard G Jung, Pietro Di Santo, Zachary D MacDonald, Robert Moreland, Trevor Simard, Aisling A Clancy, Juan J Russo, Vivian A Welch, George A Wells, Benjamin Hibbert
发表日期
2017/6/9
来源
Circulation research
卷号
120
期号
12
页码范围
1916-1926
出版商
Lippincott Williams & Wilkins
简介
Rationale:
Methodological sources of bias and suboptimal reporting contribute to irreproducibility in preclinical science and may negatively affect research translation. Randomization, blinding, sample size estimation, and considering sex as a biological variable are deemed crucial study design elements to maximize the quality and predictive value of preclinical experiments.
Objective:
To examine the prevalence and temporal patterns of recommended study design element implementation in preclinical cardiovascular research.
Methods and Results:
All articles published over a 10-year period in 5 leading cardiovascular journals were reviewed. Reports of in vivo experiments in nonhuman mammals describing pathophysiology, genetics, or therapeutic interventions relevant to specific cardiovascular disorders were identified. Data on study design and animal model use were collected. Citations at 60 months were …
学术搜索中的文章
FD Ramirez, P Motazedian, RG Jung, P Di Santo… - Circulation research, 2017