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Volpe et al Newer Aspects of the 2018 European Guidelines 973 and could be exposed to a relevant risk. Recent randomized clinical trials and meta-analyses have indeed suggested to reconsider these thresholds and most importantly, the consequent clinical behaviors. SPRINT is paradigmatically quoted to support the beneficial effect of a more intensive BP control in high-risk patients in the high-normal range. Those who were randomized to an SBP target< 120 mm Hg (intensive treatment) had a better cardiovascular outcome than those who were randomized to an SBP target< 140 mm Hg (standard treatment). 9 However, several specific methodological criticisms, mostly linked to the unique BP measurement technique, have been raised to SPRINT, 11 and although the study unequivocally shows that a tighter BP control is beneficial, 9 the implications of its results in a larger population remain controversial. The …