作者
Francesco Liotta, Valentina Querci, Giuditta Mannelli, Veronica Santarlasci, Laura Maggi, Manuela Capone, MARIA CATERINA Rossi, Alessio Mazzoni, Lorenzo Cosmi, Sergio Romagnani, Enrico Maggi, Oreste Gallo, Francesco Annunziato
发表日期
2015/2
期刊
British journal of cancer
卷号
112
期号
4
页码范围
745-754
出版商
Nature Publishing Group
简介
Background:
Cancer is a multifactorial disease not only restricted to transformed epithelium, but also involving cells of the immune system and cells of mesenchymal origin, particularly mesenchymal stem cells (MSCs). Mesenchymal stem cells contribute to blood-and lymph-neoangiogenesis, generate myofibroblasts, with pro-invasive activity and may suppress anti-tumour immunity.
Methods:
In this paper, we evaluated the presence and features of MSCs isolated from human head neck squamous cell carcinoma (HNSCC).
Results:
Fresh specimens of HNSCC showed higher proportions of CD90+ cells compared with normal tissue; these cells co-expressed CD29, CD105, and CD73, but not CD31, CD45, CD133, and human epithelial antigen similarly to bone marrow-derived MSCs (BM-MSCs). Adherent stromal cells isolated from tumour shared also differentiation potential with BM-MSCs, thus we named them as …
学术搜索中的文章
F Liotta, V Querci, G Mannelli, V Santarlasci, L Maggi… - British journal of cancer, 2015