作者
Alessandra Vultaggio, Emanuele Vivarelli, Gianni Virgili, Ersilia Lucenteforte, Alessandro Bartoloni, Carlo Nozzoli, Alessandro Morettini, Andrea Berni, Danilo Malandrino, Oliviero Rossi, Francesca Nencini, Filippo Pieralli, Adriano Peris, Filippo Lagi, Giulia Scocchera, Michele Spinicci, Michele Trotta, Marcello Mazzetti, Paola Parronchi, Lorenzo Cosmi, Francesco Liotta, Paolo Fontanari, Alessio Mazzoni, Lorenzo Salvati, Enrico Maggi, Francesco Annunziato, Fabio Almerigogna, Andrea Matucci
发表日期
2020/9/1
期刊
The Journal of Allergy and Clinical Immunology: In Practice
卷号
8
期号
8
页码范围
2575-2581. e2
出版商
Elsevier
简介
Background
The early identification of patients at risk of clinical deterioration is of interest considering the timeline of COVID-19 after the onset of symptoms.
Objective
The aim of our study was to evaluate the usefulness of testing serum IL-6 and other serological and clinical biomarkers, to predict a short-term negative clinical course of patients with noncritical COVID-19.
Methods
A total of 208 patients with noncritical COVID-19 pneumonia at admission were consecutively enrolled. Clinical and laboratory findings obtained on admission were analyzed by using survival analysis and stepwise logistic regression for variable selection. Three-day worsening as outcome in a logistic model to generate a prognostic score was used.
Results
Clinical worsening occurred in 63 patients (16 = died; 39 = transferred to intensive care unit; 8 worsening of respiratory failure). Forty-five of them worsened within 3 days after admission …
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A Vultaggio, E Vivarelli, G Virgili, E Lucenteforte… - The Journal of Allergy and Clinical Immunology: In …, 2020