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Connected and autonomous vehicles (CAVs) are developing rapidly nowadays. In the near future, we may see human-driving vehicles (HVs) and CAVs running on the same road. The characteristics of human drivers and the interaction between HVs and CAVs, therefore, need to be further studied. All these factors will have a great impact on traffic operation. This paper aims to explore a modeling method to analyze the operation mechanism of mixed traffic flows of HVs and CAVs. Considering HV drivers’ cognitive behavioral characteristics and HV–CAV interaction effects, the forward and lateral movement rules of HVs and CAVs are proposed based on the Cellular Automata model. Then the fundamental diagram, congestion degree, lane-changing frequency, and time-spatial diagram are obtained by numerical simulation. The results show that the presence of CAVs is positively related to macroscopic traffic …