作者
Amit X Garg, Jennie Pouget, Ann Young, Anjie Huang, Neil Boudville, Anthony Hodsman, Jonathan D Adachi, William D Leslie, Suzanne M Cadarette, Charmaine E Lok, Mauricio Monroy-Cuadros, GV Ramesh Prasad, Sonia M Thomas, Kyla Naylor, Darin Treleavan, Donor Nephrectomy Outcomes Research (DONOR) Network
发表日期
2012/6/1
期刊
American Journal of Kidney Diseases
卷号
59
期号
6
页码范围
770-776
出版商
WB Saunders
简介
BACKGROUND
Chronic kidney disease increases the risk of bone fragility fractures (osteoporotic fractures). Living kidney donors lose 50% of their renal mass and show changes in calcium homeostasis. We studied whether living kidney donation increases the risk of fragility fracture.
DESIGN
Retrospective matched-cohort study.
SETTING & PARTICIPANTS
We reviewed the medical charts of all 2,015 adults in Ontario, Canada, who donated a kidney between 1992 and 2009 (surgeries performed across 5 transplant programs). We linked this information to health care databases and randomly selected 20,150 matched nondonors from the healthiest portion of the general population. Median age was 43 (95% CI, 24-50) years at study enrollment. Donors and nondonors were then followed up for a median of 6.6 years and a maximum of 17.7 years.
PREDICTOR
Living donor nephrectomy.
OUTCOMES
The primary …
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AX Garg, J Pouget, A Young, A Huang, N Boudville… - American journal of kidney diseases, 2012