作者
J Richard Pilsner, Hachem Saddiki, Brian W Whitcomb, Alexander Suvorov, Germaine M Buck Louis, Sunni L Mumford, Enrique F Schisterman, Oladele A Oluwayiose, Laura B Balzer
发表日期
2022/7/1
期刊
Human Reproduction
卷号
37
期号
7
页码范围
1581-1593
出版商
Oxford University Press
简介
STUDY QUESTION
Is sperm epigenetic aging (SEA) associated with probability of pregnancy among couples in the general population?
SUMMARY ANSWER
We observed a 17% lower cumulative probability at 12 months for couples with male partners in the older compared to the younger SEA categories.
WHAT IS KNOWN ALREADY
The strong relation between chronological age and DNA methylation profiles has enabled the estimation of biological age as epigenetic ‘clock’ metrics in most somatic tissue. Such clocks in male germ cells are less developed and lack clinical relevance in terms of their utility to predict reproductive outcomes.
STUDY DESIGN, SIZE, DURATION
This was a population-based prospective cohort study of couples discontinuing contraception to become pregnant recruited from 16 US counties from 2005 to …
学术搜索中的文章
JR Pilsner, H Saddiki, BW Whitcomb, A Suvorov… - Human Reproduction, 2022