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Amyloid burden and vascular risk factors correlate with regional cerebral blood flow in a cognitively unimpaired population

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Beatriz E Padrela, Luigi Lorenzini, Lyduine E Collij, Mara ten Kate, Anouk den Braber, Jori Tomassen, Mahnaz Shekari, Bart NM van Berckel, Pieter Jelle Visser, Frederik Barkhof, Jan Petr, Henk JMM Mutsaerts

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Recent findings indicate considerable overlap between cerebrovascular disease and Alzheimer's disease(AD), suggesting additive or synergistic effects of both pathologies on cognitive decline[1, 2]. As cerebrovascular and Alzheimer's proteinopathy have previously shown to affect cerebral blood flow (CBF) as well as cognition, CBF could be a potential early hemodynamic biomarker of cognitive decline. Here, we investigated to what extent cardiovascular risk factors and amyloid burden affect CBF in an elderly cognitively unimpaired (CU) population.

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Amyloid burden and vascular risk factors correlate with regional cerebral blood flow in a cognitively unimpaired population

BE Padrela, L Lorenzini, LE Collij, M ten Kate…