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Amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI is a potentially useful clinical technique to image brain tumors, but its reproducibility was not yet investigated in detail. Our 3T scan-rescan protocol on volunteers and glioma patients revealed high within-session and slightly lower in-between-session and between-day reproducibility, with highest reproducibility occipitally and centrally in the brain and lowest at the skull base. The within-session reproducibility for patients was also good, both intratumoral and extratumoral. These results show that APT-CEST at 3T MRI renders reproducible values allowing for clinical monitoring of metabolic brain tumors.