作者
Richard C Gerkin, Kathrin Ohla, Maria G Veldhuizen, Paule V Joseph, Christine E Kelly, Alyssa J Bakke, Kimberley E Steele, Michael C Farruggia, Robert Pellegrino, Marta Y Pepino, Cédric Bouysset, Graciela M Soler, Veronica Pereda-Loth, Michele Dibattista, Keiland W Cooper, Ilja Croijmans, Antonella Di Pizio, Mehmet Hakan Ozdener, Alexander W Fjaeldstad, Cailu Lin, Mari A Sandell, Preet B Singh, V Evelyn Brindha, Shannon B Olsson, Luis R Saraiva, Gaurav Ahuja, Mohammed K Alwashahi, Surabhi Bhutani, Anna D’errico, Marco A Fornazieri, Jérôme Golebiowski, Liang Dar Hwang, Lina Öztürk, Eugeni Roura, Sara Spinelli, Katherine L Whitcroft, Farhoud Faraji, Florian Ph S Fischmeister, Thomas Heinbockel, Julien W Hsieh, Caroline Huart, Iordanis Konstantinidis, Anna Menini, Gabriella Morini, Jonas K Olofsson, Carl M Philpott, Denis Pierron, Vonnie DC Shields, Vera V Voznessenskaya, Javier Albayay, Aytug Altundag, Moustafa Bensafi, María Adelaida Bock, Orietta Calcinoni, William Fredborg, Christophe Laudamiel, Juyun Lim, Johan N Lundström, Alberto Macchi, Pablo Meyer, Shima T Moein, Enrique Santamaría, Debarka Sengupta, Paloma Rohlfs Dominguez, Hüseyin Yanik, Thomas Hummel, John E Hayes, Danielle R Reed, Masha Y Niv, Steven D Munger, Valentina Parma
发表日期
2021/1/1
期刊
Chemical senses
卷号
46
页码范围
bjaa081
出版商
Oxford University Press
简介
In a preregistered, cross-sectional study, we investigated whether olfactory loss is a reliable predictor of COVID-19 using a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0–100 visual analog scales (VAS) for participants reporting a positive (C19+; n = 4148) or negative (C19−; n = 546) COVID-19 laboratory test outcome. Logistic regression models identified univariate and multivariate predictors of COVID-19 status and post-COVID-19 olfactory recovery. Both C19+ and C19− groups exhibited smell loss, but it was significantly larger in C19+ participants (mean ± SD, C19+: −82.5 ± 27.2 points; C19−: −59.8 ± 37.7). Smell loss during illness was the best predictor of COVID-19 in both univariate and multivariate models (ROC AUC = 0.72 …
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RC Gerkin, K Ohla, MG Veldhuizen, PV Joseph… - Chemical senses, 2021