作者
Noémie Letellier, Laure‐Anne Gutierrez, Jeanne Duchesne, Chen Chen, Sindana Ilango, Catherine Helmer, Claudine Berr, Marion Mortamais, Tarik Benmarhnia
发表日期
2022/12
期刊
Alzheimer's & Dementia
卷号
18
期号
12
页码范围
2509-2517
简介
Introduction
No evidence exists about the impact of air pollution reduction on incidence of dementia. The aim of this study was to quantify how air quality improvement leads to dementia‐incidence benefits.
Methods
In the French Three‐City cohort (12 years of follow‐up), we used parametric g‐computation to quantify the expected number of prevented dementia cases under different hypothetical interventions with particulate matter measuring <2.5 μm (PM2.5) reductions.
Results
Among 7051 participants, 789 participants developed dementia. The median PM2.5 reduction between 1990 and 2000 was 12.2 (μg/m3). Such a reduction reduced the risk of all‐cause dementia (hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.76 to 0.95). If all study participants were enjoying a hypothetical reduction of more than 13.10 μg/m3 (median reduction observed in the city of Montpellier), the rate difference was −0.37 (95 …
学术搜索中的文章
N Letellier, LA Gutierrez, J Duchesne, C Chen, S Ilango… - Alzheimer's & Dementia, 2022