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An implantable wireless glucose monitoring SoC with hydrogel-based glucose sensor is proposed in CMOS 0.35 um technology. Owing to the reusable nature of the hydrogel glucose sensor and the wireless readout ability of the circuitry, this SoC is suitable for long-term and continuous monitoring. In-Vitro test shows a resolution of 40 mMole in glucose detection. The total power consumption of the SoC is 285 nW in standby mode and 11.9 mW in data transmission mode.