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Internet of Things (IoT) is an emerging domain that promises ubiquitous connection to the Internet, turning common objects into connected devices. The IoT paradigm is changing the way people interact with things around them. It paves the way for creating pervasively connected infrastructures to support innovative services and promises better flexibility and efficiency. Such advantages are attractive not only for consumer applications, but also for the industrial domain. Over the last few years, we have been witnessing the IoT paradigm making its way into the industry marketplace with purposely designed solutions. In this paper, we clarify the concepts of IoT, Industrial IoT, and Industry 4.0. We highlight the opportunities brought in by this paradigm shift as well as the challenges for its realization. In particular, we focus on the challenges associated with the need of energy efficiency, real-time performance, coexistence …