作者
Arnold F Jacobson, Roxy Senior, Manuel D Cerqueira, Nathan D Wong, Gregory S Thomas, Victor A Lopez, Denis Agostini, Fred Weiland, Harish Chandna, Jagat Narula, ADMIRE-HF Investigators
发表日期
2010/5/18
期刊
Journal of the American College of Cardiology
卷号
55
期号
20
页码范围
2212-2221
出版商
American College of Cardiology Foundation
简介
Objectives
The ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study prospectively evaluated iodine-123 meta-iodobenzylguanidine (123I-mIBG) imaging for identifying symptomatic heart failure (HF) patients most likely to experience cardiac events.
Background
Single-center studies have demonstrated the poorer prognosis of HF patients with reduced 123I-mIBG myocardial uptake, but these observations have not been validated in large multicenter trials.
Methods
A total of 961 subjects with New York Heart Association (NYHA) functional class II/III HF and left ventricular ejection fraction (LVEF) ≤35% were studied. Subjects underwent 123I-mIBG myocardial imaging (sympathetic neuronal integrity quantified as the heart/mediastinum uptake ratio [H/M] on 4-h delayed planar images) and myocardial perfusion imaging and were then followed up for up to 2 years. Time to first occurrence …
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