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Cancer is a group of diseases that involve abnormal cell growth with the potential to spread to other parts of the body. Cancer microarray data usually include a small number of samples with a large number of gene expression levels as features. Gene expression or microarray is a technology that monitors the expression of the large number of genes in parallel that make it useful in cancer classification, high dimensionality in cancer microarray data results in the overfitting problem. This article proposes novel hybrid feature selection model called the RBARegulizer model, which is based on two types of feature selection techniques, two RBAs algorithms (ReliefF, MultiSURF) for feature‐ranking filters to the most important one's genes, and three regulizer algorithms (Lasso, Elastic Net, Elastic Net CV) to reduce the feature subset, remove the noisy and irrelevant feature to improve the performance and accuracy of …