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Surgery remains a cornerstone of oncology treatment, and minimally invasive approaches, enhanced recovery pathways (ERPs), and other interventions have improved safety and patient outcomes. 1 However, despite these advances, major cancer resections of the bladder, pancreas, lung, or esophagus have mortalities of 4% to 9% 2 and high morbidities persist even for lower-risk procedures like colorectal resection, ranging from 25% to 50%. 3 Postoperative complications prolong hospital lengths of stay, increase readmissions and elevate costs, impact patient functioning and quality of life, and may have long-term implications on mortality. 4 Tissue trauma, reduced physical activity, quasi-starvation, and psychological distress associated with major surgery result in a rapid decline in functional capacity, followed by slow recovery. 5 At-risk populations, including the elderly, are more susceptible to the negative …