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Multimodal image registration is becoming increasingly important in remote sensing. However, due to the significant nonlinear intensity differences between multimodal images, conventional registration methods tend to get trapped into local optima. To address this issue, we present a new approach for multimodal image registration using histogram of oriented gradient distance (HOGD) and data-driven grey wolf optimizer (DDGWO). First, we propose a novel similarity measure for area-based registration methods that is HOGD. We investigate the performance of HOGD by analyzing its similarity curve. HOGD has a large range of values, which is helpful to find the global optimum. Second, we use GWO to optimize the transformation parameters. Since it is time-consuming to calculate HOGD, we propose DDGWO to minimize HOGD. In DDGWO, the iterations are divided into two parts: the training and prediction …