作者
Xiangyu Zhang, Zheng Wang, Wanxiangfu Tang, Xinyu Wang, Rui Liu, Hua Bao, Xin Chen, Yulin Wei, Shuyu Wu, Hairong Bao, Xue Wu, Yang Shao, Jia Fan, Jian Zhou
发表日期
2022/8
期刊
Hepatology
卷号
76
期号
2
页码范围
317-329
简介
Background and Aims
Early detection of primary liver cancer (PLC), including HCC, intrahepatic cholangiocarcinoma (ICC), and combined HCC‐ICC (cHCC‐ICC), is essential for patients’ survival. This study aims to develop an accurate and affordable method for PLC early detection and differentiating ICC from HCC using plasma cell‐free DNA (cfDNA) fragmentomic profiles.
Approach and Results
Whole‐genome sequencings (WGS) were performed using plasma cfDNA samples from 192 patients with PLC (159 HCC, 26 ICC, 7 cHCC‐ICC) and 170 noncancer controls (including 53 liver cirrhosis [LC] or HBV‐positive) enrolled in the training cohort. An ensembled stacked model for PLC detection was constructed using the training cohort. The model performance was assessed in an independent test cohort (189 patients with PLC [157 HCC, 26 ICC, 6 cHCC‐ICC], 164 noncancer controls [including 51 LC/HBV …
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