作者
Shaobo Mo, Li Ye, Dongyang Wang, Lingyu Han, Shuang Zhou, Hui Wang, Weixing Dai, Yichao Wang, Wenqin Luo, Renjie Wang, Ye Xu, Sanjun Cai, Rui Liu, Zheng Wang, Guoxiang Cai
发表日期
2023/6/1
期刊
JAMA oncology
卷号
9
期号
6
页码范围
770-778
出版商
American Medical Association
简介
Importance
Detection of molecular residual disease and risk stratification as early as possible may improve the treatment of patients with cancer. Efficient pragmatic tests are therefore required.
Objective
To measure circulating tumor DNA (ctDNA) with 6 DNA methylation markers in blood samples and to evaluate the association of the presence of ctDNA with colorectal cancer (CRC) recurrence throughout the disease course.
Design, Setting, and Participants
In this multicenter prospective longitudinal cohort study performed from December 12, 2019, to February 28, 2022, 350 patients with stage I to III CRC were recruited from 2 hospitals for collection of blood samples before and after surgery, during and after adjuvant chemotherapy, and every 3 months for up to 2 years. A multiplex, ctDNA methylation, quantitative polymerase chain reaction assay was used to detect ctDNA in plasma samples.
Results
A total of 299 …
学术搜索中的文章
S Mo, L Ye, D Wang, L Han, S Zhou, H Wang, W Dai… - JAMA oncology, 2023