作者
Guoxiang Cai, Mingyan Cai, Zhiqiang Feng, Rui Liu, Li Liang, Pinghong Zhou, Boqun Zhu, Shaobo Mo, Hui Wang, Xiaoliang Lan, Sanjun Cai, Ye Xu, Renjie Wang, Weixin Dai, Lingyu Han, Wenqiang Xiang, Beili Wang, Wei Guo, Lijing Zhang, Changjiang Zhou, Binyang Luo, Yingfei Li, Yuqiang Nie, Chengcheng Ma, Zhixi Su
发表日期
2021/12/1
期刊
Gastroenterology
卷号
161
期号
6
页码范围
2053-2056. e2
出版商
Elsevier
简介
Colorectal cancer (CRC) is one of the most common and deadliest cancers worldwide. Patient survival can be greatly improved if cancerous lesions are detected early. 1 Despite a strong recommendation of colonoscopy for CRC screening, patients prefer noninvasive tests, and 83% favor blood-based tests. 2 Blood tests that rely on a single DNA methylation biomarker have been approved 3; however, they are not recommended due to the low sensitivity for detecting early-stage CRC. 4 Another unmet clinical need in CRC is the postoperative surveillance for early signs of recurrent disease. 5 Follow-up strategies, such as serum carcinoembryonic antigen (CEA), have limited sensitivity or nonspecific findings. 6, 7 More accurate blood-based tests are therefore desired to facilitate monitoring. Here we describe the development, validation, and implementation of ColonAiQ, a multilocus blood test for detecting CRC …
学术搜索中的文章
G Cai, M Cai, Z Feng, R Liu, L Liang, P Zhou, B Zhu… - Gastroenterology, 2021